It's not clear without a more detailed analysis of what's going on with the remote PC. Some users had indicated in the past that having FastStart enabled caused the issues for them and disabling it fixed the issue. You can read more about how to disable FastStart here: https://www.windowscentral.com/how-disable-windows-10-fast-startup

Other had corrected the issue by restarting the Remote Assistant Service on the remote system. But usually this was only a temporary fix.

There was also a fix for a similar issue in 2.3.1 (and another in the 2.3 release), so make sure you are using the latest version.

You may want to open a support case from the menu - Diagnostic option on the remote system where you are unable to connect.

Thanks for the response, David. There won't be anyone at the office to check that computer until later today. The remote PC is on 24/7 and not restarted very often, it's been at least a month or more. And I've been connecting daily with no issues until now. I have updated my home PC to 2.3.1.5, but not the remote PC in the office, don't know if that would make any difference, but this issue started last Thursday and I updated MSP360 on this computer over the weekend to see if it would help. The office PC version is whatever it was when first installed several months ago.

I'll respond later today after someone is in the office.